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Related Experiment Videos

Biochemical studies on equine infectious anaemia.

E Palomba, F Martone, A Meduri

    Folia Veterinaria Latina
    |July 1, 1976
    PubMed
    Summary

    Equine infectious anaemia (EIA) in horses causes significant increases in enzymes like LDH and copper. Diagnosis involves clinical, pathological, and serological tests, including the Coggins test.

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    Area of Science:

    • Veterinary Medicine
    • Infectious Diseases
    • Biochemistry

    Background:

    • Equine infectious anaemia (EIA) is a significant viral disease affecting horses.
    • An outbreak of EIA occurred in Campania, Italy, impacting equine health in the region.

    Purpose of the Study:

    • To investigate biochemical alterations in horses affected by EIA.
    • To identify key biomarkers associated with EIA during an outbreak.

    Main Methods:

    • Diagnosis of EIA confirmed through clinical, pathological, and serological examinations, including the Coggins test.
    • Serum analysis of 45 EIA-positive horses and 11 healthy controls.
    • Comprehensive biochemical profiling, including enzyme activities, coagulation factors, lipids, and copper levels.

    Main Results:

    • Significant elevations observed in lactate dehydrogenase (LDH), leucine aminopeptidase (LAP), gamma-glutamyl transpeptidase (gamma-GT), creatine phosphokinase (CPK), pyruvate kinase (PK), aldolase (ALD), and copper levels.
    • Insignificant increases noted in other enzymes, intrinsic coagulation factors, lipid profiles (cholesterol, triglycerides), and glucose.
    • Lactate dehydrogenase-1 isoenzyme remained unchanged, while acid phosphatase (AcP) showed a slight decrease.

    Conclusions:

    • EIA is associated with marked alterations in specific enzyme activities and copper metabolism.
    • Biochemical markers can aid in understanding the pathophysiology of EIA.
    • The findings provide insights into the systemic effects of EIA in horses.

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