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Related Experiment Videos

Hypothermia dn alphamethyldopa treatment.

M Chandramohan, N Hariharasubramanian, E S Johnson

    Indian Journal of Physiology and Pharmacology
    |October 1, 1976
    PubMed
    Summary

    Alphamethyldopa, a drug that lowers blood pressure, can cause hypothermia in some patients by inhibiting serotonin synthesis. This effect was observed in hypertensive patients with cerebral atherosclerosis.

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    Area of Science:

    • Pharmacology
    • Neuroscience
    • Cardiology

    Background:

    • Alphamethyldopa is a hypotensive agent known to inhibit serotonin synthesis.
    • Serotonin plays a role in thermoregulation.
    • Cerebral atherosclerosis may influence drug responses.

    Purpose of the Study:

    • To investigate the incidence and characteristics of hypothermia induced by alphamethyldopa.
    • To explore the relationship between alphamethyldopa's anti-serotonin effect and hypothermia.
    • To examine the potential role of cerebral atherosclerosis in this side effect.

    Main Methods:

    • Observational study of nine hypertensive patients treated with alphamethyldopa.
    • Monitoring of body temperature and 24-hour urinary 5-hydroxyindoleacetic acid (5-HIAA) levels.
    • Correlation analysis between drug therapy, serotonin metabolite levels, and body temperature.

    Main Results:

    • Four out of nine patients developed significant hypothermia (33.4-34.8°C).
    • Alphamethyldopa treatment led to a statistically significant decrease in 24-hour urinary 5-HIAA levels.
    • The anti-serotonin effect correlated with the observed hypothermia.

    Conclusions:

    • Alphamethyldopa can induce hypothermia, particularly in hypertensive patients with cerebral atherosclerosis.
    • The hypothermic side effect is likely linked to alphamethyldopa's inhibition of serotonin synthesis.
    • Further research is needed to elucidate the precise mechanism of this adverse effect.

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