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Related Experiment Videos

Fiber, lipids, and atherosclerosis.

D Kritchevsky

    The American Journal of Clinical Nutrition
    |October 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Dietary fiber impacts lipid metabolism and atherosclerosis. Certain fibers like pectin and guar gum can lower cholesterol in humans and animals, while others have no significant effect.

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    The Journal of nutritional biochemistry·2002

    Area of Science:

    • Nutrition Science
    • Cardiovascular Research
    • Metabolic Studies

    Background:

    • Dietary fiber's role in health is increasingly recognized.
    • Understanding its impact on lipid metabolism and atherosclerosis is crucial for public health.
    • Variations in fiber composition affect physiological outcomes.

    Purpose of the Study:

    • To review the influence of dietary fiber on lipid metabolism.
    • To examine the effects of various fibers on atherosclerosis development in animal models.
    • To synthesize findings on fiber's impact on human lipid profiles.

    Main Methods:

    • Literature review of animal studies (rats, rabbits, baboons, monkeys) and human trials.
    • Analysis of serum and liver cholesterol levels in response to different dietary fibers.

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  • Assessment of atherosclerosis markers, including aortic sudanophilia.

    • Main Results:

    • Pectin, guar gum, and lignin reduced serum/liver cholesterol in rats.
    • Agar increased liver cholesterol in rats; bran had no effect.
    • Pectin and guar gum lowered cholesterol in humans; cellulose and bran did not.
    • Semipurified diets, especially with cellulose, promoted atherosclerosis in rabbits, baboons, and monkeys.

    Conclusions:

    • Specific dietary fibers (pectin, guar gum) demonstrate hypolipidemic effects.
    • Fiber's impact on atherosclerosis is diet composition-dependent.
    • Binding of bile acids is a potential mechanism for fiber's cholesterol-lowering action.