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Related Experiment Videos

The bioavailability of quinine.

J C Garnham, K Raymond, E Shotton

    The Journal of Tropical Medicine and Hygiene
    |December 1, 1976
    PubMed
    Summary

    This study compared quinine salt tablet formulations. Plain tablets released quinine dihydrochloride fastest, followed by bisulphate and sulphate, while sugar-coated tablets showed delayed release and lower bioavailability.

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    Absence of Low-Energy Shape Coexistence in ^{80}Ge: The Nonobservation of a Proposed Excited 0_{2}^{+} Level at 639 keV.

    Physical review letters·2020

    Area of Science:

    • Pharmaceutical Sciences
    • Drug Delivery Systems

    Background:

    • Quinine salts are used for malaria treatment.
    • Understanding salt form impact on drug release is crucial for formulation development.

    Purpose of the Study:

    • To evaluate the in vitro and in vivo performance of different quinine salt formulations.
    • To compare the release characteristics of plain and sugar-coated quinine tablets.

    Main Methods:

    • Preparation of plain and sugar-coated tablets using quinine dihydrochloride, bisulphate, and sulphate.
    • In vitro disintegration and dissolution testing using a dialysis method with forced convection and sink conditions.
    • In vivo bioavailability studies.

    Main Results:

    • Plain tablets exhibited release in the order: dihydrochloride > bisulphate > sulphate.
    • Sugar-coated tablets demonstrated protracted disintegration and dissolution, leading to delayed release.
    • In vivo studies confirmed lower bioavailability for sugar-coated formulations compared to plain tablets.

    Conclusions:

    • The salt form of quinine significantly influences tablet disintegration, dissolution, and in vivo bioavailability.
    • Sugar-coating delays quinine release, impacting its overall availability.

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