Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

An algorithm for drug waste reduction using pharmacokinetic principles.

F van den Bosch1, D J Doyle

  • 1Institute of Biomedical Engineering, University of Toronto, Canada.

Journal of Clinical Engineering
|January 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Focus Expansion in Plant Disease. I: The Constant Rate of Focus Expansion.

Phytopathology·2025
Same author

Performance of cut-offs of the ASAS Health Index to discriminate between treatment groups in patients with axial spondyloarthritis in the TICOSPA trial.

Seminars in arthritis and rheumatism·2024
Same author

Translating surveillance data into incidence estimates.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2019
Same author

Plant Virus Epidemiology: Applications and Prospects for Mathematical Modeling and Analysis to Improve Understanding and Disease Control.

Plant disease·2019
Same author

Epidemiology: Past, Present, and Future Impacts on Understanding Disease Dynamics and Improving Plant Disease Management-A Summary of Focus Issue Articles.

Phytopathology·2017
Same author

Association of Comorbidities in Spondyloarthritis With Poor Function, Work Disability, and Quality of Life: Results From the Assessment of SpondyloArthritis International Society Comorbidities in Spondyloarthritis Study.

Arthritis care & research·2017
Same journal

US Food and Drug Administration Seeks Input From Healthcare Technology Management Community on Medical Device Supply Disruption During COVID-19 Pandemic.

Journal of clinical engineering·2021
Same journal

Observations on COVID-19.

Journal of clinical engineering·2021
Same journal

Medical computing over the World Wide Web: use of forms and CGI scripts for constructing medical algorithm Web pages.

Journal of clinical engineering·1999
Same journal

Utilization of the Internet to deliver educational materials to healthcare professionals.

Journal of clinical engineering·1999
Same journal

Computer-aided learning--a solution for the training needs of users & maintainers of medical equipment.

Journal of clinical engineering·1999
Same journal

A study on the current situation in the biomedical technology and clinical engineering sector in Bulgaria--advances, trends and needs.

Journal of clinical engineering·1999
See all related articles

This study presents an algorithm to minimize intravenous drug waste by calculating optimal timing for remaining doses. This approach ensures desired peak serum drug concentrations, reducing costs associated with aminoglycoside administration.

Area of Science:

  • Pharmacokinetics
  • Pharmacodynamics
  • Drug administration

Background:

  • Intravenous drug administration often results in drug waste when remaining amounts are insufficient for subsequent doses.
  • This waste is particularly notable with drugs requiring precise dosing, such as aminoglycosides.
  • Reducing drug waste can lead to significant cost savings in healthcare.

Purpose of the Study:

  • To develop and validate an algorithm for complete utilization of intravenous drug from a single bag.
  • To ensure achievement of target peak serum drug concentrations with optimized dosing.
  • To reduce the economic burden of drug administration, specifically for aminoglycosides.

Main Methods:

  • Development of an algorithm based on standard pharmacokinetic equations for single-compartment, first-order linear kinetics.

Related Experiment Videos

  • Input parameters include bag time limit, dosing interval, and dose size.
  • Algorithm calculates the optimal time to administer remaining drug to achieve desired peak concentration.

    • Main Results:

    • The algorithm enables the administration of all drug from a single bag, minimizing waste.
    • It accurately predicts the timing for remaining doses to achieve target peak serum drug concentrations.
    • Potential for cost reduction in aminoglycoside administration through decreased drug waste.

    Conclusions:

    • The developed algorithm effectively minimizes intravenous drug waste by optimizing the administration of remaining drug.
    • This method is applicable to drugs with single-compartment, first-order linear kinetics and can be adapted for other models.
    • Integration with computer-assisted infusion can further enhance efficiency and cost-effectiveness in drug delivery.