Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Absorption and malabsorption of folates.

I H Rosenberg

    Clinics in Haematology
    |October 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Folate absorption is a complex process primarily limited by monoglutamyl folate transport. Malabsorption occurs when this transport is impaired, impacting intestinal function and potentially leading to deficiency.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    B-Vitamin Therapy for Kidney Transplant Recipients Lowers Homocysteine and Improves Selective Cognitive Outcomes in the Randomized FAVORIT Ancillary Cognitive Trial.

    The journal of prevention of Alzheimer's disease·2017
    Same author

    Nutrition and the biology of human ageing: proceedings of the Ninth Nestlé International Nutrition Symposium.

    The journal of nutrition, health & aging·2013
    Same author

    25-Hydroxyvitamin D, dementia, and cerebrovascular pathology in elders receiving home services.

    Neurology·2009
    Same author

    Metabolic programming of offspring by vitamin B12/folate imbalance during pregnancy.

    Diabetologia·2007
    Same author

    Multivitamin use and B vitamin status in a homebound elderly population.

    The journal of nutrition, health & aging·2007
    Same author

    Plasma homocysteine and parental myocardial infarction in young adults in Jerusalem.

    Circulation·2002
    Same journal

    Myelodysplastic syndromes.

    Clinics in haematology·1986
    Same journal

    In vitro culture techniques defining biological abnormalities in the myelodysplastic syndromes and myeloproliferative disorders.

    Clinics in haematology·1986
    Same journal

    Myelodysplastic syndromes: natural history and features of prognostic importance.

    Clinics in haematology·1986
    Same journal

    Pathogenesis and clinical variations in the myelodysplastic syndromes.

    Clinics in haematology·1986
    Same journal

    The treatment of myelodysplastic syndromes.

    Clinics in haematology·1986
    Same journal

    Secondary myelodysplastic syndromes and leukaemias.

    Clinics in haematology·1986
    See all related articles

    Area of Science:

    • Nutritional Biochemistry
    • Gastroenterology

    Background:

    • Folic acid (pteroylglutamic acid) and its conjugates have been extensively studied.
    • Folate absorption is a key indicator of intestinal function.

    Purpose of the Study:

    • To elucidate the mechanisms of folate absorption and malabsorption.
    • To identify factors influencing folate transport and metabolism in the intestine.

    Main Methods:

    • Studies involving synthetic radiolabelled pteroylpolyglutamates.
    • Analysis of folate absorption in disease and drug interactions.

    Main Results:

    • Polyglutamyl folates are hydrolyzed at the intestinal border, with released folate efficiently absorbed.
    • Monoglutamyl folate transport is the rate-limiting step in folate absorption.

    Related Experiment Videos

  • Folate malabsorption is linked to depressed monoglutamyl transport.

    • Conclusions:

    • Understanding folate transport and metabolism is crucial for managing folate deficiency in gastrointestinal diseases and with drug therapy.
    • Further research is needed on folate binding proteins and epithelial cell release mechanisms.