In the years before Newton, a general belief prevailed that different laws governed objects in the sky than objects on Earth. When Kepler wrote down the three laws of planetary motion, explaining in detail the geometrical properties of the planetary orbits around the Sun, there was no immediate idea to discern their connection with more fundamental laws. It was Isaac Newton who, in 1665–66, figured out the connection between planetary motion, the motion of the moon around the Earth, and...

Gravitation is one of the four fundamental forces in nature. The force between objects on Earth and Earth itself is called gravity.
Like other forces, gravity does work on an object if it displaces it toward the Earth's center. In this case, the work done by gravity is said to be positive. If an external force acts on the object against the pull of gravity and manages to lift it away from the Earth's center, work is done against gravity. In this case, the net work done is said to be...

Potential energy is not just a property of each object, but also a property of the interactions between objects in a chosen system. For each type of interaction present in a system, there is a corresponding type of potential energy. The total potential energy of the system is the sum of the potential energies of all the objects. Potential energy can be classified into two major categories: gravitational potential energy and elastic potential energy. The potential energy associated with a...

A critical value is a definite value obtained from a particular probability distribution at a predecided confidence level (or a predecided significance level) for a given population parameter. The critical value provides demarcation that separates the sample statistics that are likely to occur from the ones that are unlikely to occur based on the given probability distribution and the population parameter to be estimated. The critical value for normal distribution is obtained from the z...

Some receptors remain unoccupied even when an agonist produces a maximal response. Such empty ones are called spare receptors. In presence of spare receptors the maximum effect of an agonist drug is achieved with fewer than 100% of the receptors being occupied. To determine the presence of spare receptors, scientists often compare the concentration of the drug needed to produce 50% of the maximum effect (EC50) with the concentration of the drug needed to occupy 50% of the receptors (Kd). If the...

Precipitation gravimetry is based on converting an analyte into a sparingly soluble precipitate, which is separated by filtration and weighed. An ideal precipitate should be pure, insoluble, of known composition, and easily filtered from the reaction mixture.
In determining nickel by gravimetric analysis, a precipitant of ethanolic dimethylglyoxime is added to a hot nickel salt solution. This is quickly followed by the dropwise addition of dilute ammonia solution until precipitation occurs. A...