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Prescribing for unlabeled indications.

J Serradell1, B Galle

  • 1Philadelphia College of Pharmacy and Science, PA.

HMO Practice
|February 7, 1993
PubMed
Summary
This summary is machine-generated.

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Physicians frequently prescribe drugs for unlabeled indications, with 88% using them off-label. This practice, involving drugs for unapproved uses, impacts healthcare policy and patient treatment decisions.

Area of Science:

  • Pharmacology and Therapeutics
  • Health Services Research

Background:

  • Physician prescribing of drugs for unapproved indications (off-label use) is common but not well understood.
  • Understanding off-label prescribing is crucial for policy and clinical practice decisions.

Purpose of the Study:

  • To investigate the prevalence and patterns of off-label drug prescribing among physicians.
  • To identify physician attitudes and information sources regarding off-label drug use.

Main Methods:

  • A 17-item questionnaire was administered to 251 physicians, many in managed care settings.
  • Physicians reported on their use of specific drugs for both labeled and unlabeled indications.
  • Physicians also listed drugs commonly used for unlabeled indications.

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Main Results:

  • 88% of physicians reported prescribing drugs for unlabeled indications.
  • Approximately 25% of physicians prescribed off-label on a daily basis.
  • Descriptive data on information sources for new drug uses were collected.

Conclusions:

  • Off-label prescribing is a widespread practice among physicians.
  • The findings highlight the need for further research and policy considerations regarding off-label drug use.
  • Efficacy and payment issues associated with off-label prescribing warrant attention.