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Medication use patterns in HIV-positive patients.

R Chow1, T Chin, I W Fong

  • 1Princess Margaret Hospital, Toronto.

The Canadian Journal of Hospital Pharmacy
|August 1, 1993
PubMed
Summary
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HIV patients often use multiple prescription and over-the-counter drugs, leading to over 80% experiencing adverse reactions and over 70% non-compliance. This highlights the need for pharmacist involvement in managing complex medication regimens for HIV care.

Area of Science:

  • Pharmacology
  • Infectious Diseases
  • Public Health

Background:

  • Patients with Human Immunodeficiency Virus (HIV) infection or Acquired Immunodeficiency Syndrome (AIDS) frequently require multiple medications.
  • Managing polypharmacy in this population is crucial for treatment efficacy and patient safety.

Purpose of the Study:

  • To document drug utilization patterns in an outpatient HIV-positive population.
  • To identify potential drug-related problems in ambulatory HIV patients.

Main Methods:

  • One-on-one interviews were conducted with 26 HIV-positive patients.
  • Data collected included prescription and non-prescription drug use, adverse drug reactions, and allergies.

Main Results:

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  • Over 90% of patients received antiretroviral therapy and anti-infective agents.
  • Approximately 70% used three or more prescription medications concurrently.
  • Every patient used at least one over-the-counter product, with over half using three or more.
  • Over 80% reported adverse reactions, primarily linked to zidovudine.
  • Over 70% experienced non-compliance, often by omitting doses.

    • Conclusions:

    • The concurrent use of multiple medications in ambulatory HIV-positive patients poses significant drug-related problems.
    • These issues can impact the efficacy and toxicity of HIV therapies.
    • Pharmacists are essential in providing direct care and managing medication-related challenges for HIV patients.