Central action of prostaglandin F2alpha on circulatory system in rats

PGF2alpha administered into the lateral brain ventricle of anesthetized rats caused an increase of the blood pressure and heart rate. Reserpine, chemical sympathectomy of the CNS with 6-hydroxydopamine (6-OHDA), atropine, and vagotomy weakened the central action of PGF2alpha on the peripheral circulation. Propranolol and phenoxybenzamine exerted no influence. Neither reserpine nor 6-OHDA changed the influence of iv injected PGF2alpha on the circulation. The results of the experiments indicate to the participation of the central catecholamines in the mechanism of central action of the PGF2alpha on the circulatory system.