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Studies on the central activity of kinins
Polish Journal of Pharmacology and Pharmacy
|November 1, 1976
Summary
Bradykinin and kallikrein influence brain neurotransmitters. Kinins reduce noradrenaline and dopamine levels but increase serotonin, particularly in the corpus striatum and hypothalamus.
Area of Science:
- Neuroscience
- Pharmacology
- Biochemistry
Background:
- Bradykinin and kallikrein are peptides involved in various physiological processes.
- Neurotransmitter levels are crucial for brain function and behavior.
Purpose of the Study:
- To investigate the effects of bradykinin and kallikrein on neurotransmitter levels in different brain regions.
- To correlate these neurochemical changes with known behavioral effects of kinins.
Main Methods:
- Measurement of noradrenaline (NA), dopamine (DA), and serotonin (5-HT) levels.
- Assay of NA and DA metabolites (normetanephrine, homovanillic acid - HVA) and 5-HT metabolite (5-hydroxyindoleacetic acid - 5-HIAA).
- Analysis across multiple brain regions: cerebellum, corpus striatum, cortex, hippocampus, hypothalamus, medulla oblongata, and midbrain.
Main Results:
- Kinins significantly decreased NA and DA levels and their metabolites.
- Kinins increased 5-HT and 5-HIAA levels.
- These effects were particularly pronounced in the corpus striatum and hypothalamus.
Conclusions:
- Bradykinin and kallikrein modulate key monoamine neurotransmitter systems in the brain.
- The observed neurochemical changes provide a potential mechanistic link to the behavioral effects of kinins.