Influence of kinins on amphetamine activity

Bradykinin (2 mug ivc) or kallikrein (40 U/kg) inhibited the stimulatory psychomotoric action of a low (0.5 mg/kg) dose of amphetamine, and potentiated the action of a high (2 mg/kg) dose of the drug. A treatment with bradykinin and the low dose of amphetamine reduced the noradrenaline and enhanced the serotonin level in the striatum, and lowered the dopamine content in the cortex, while a combined treatment with the high dose of amphetamine elevated the dopamine level in the striatum and hypothalamus and depressed the serotonin level in the midbrain.