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Related Concept Videos

Drug Nomenclature01:17

Drug Nomenclature

During the development of a new pharmaceutical, the manufacturer initially assigns a code name to the drug. Once approved, the drug receives a United States Adopted Name (USAN)—a generic, nonproprietary designation. Upon being listed in the United States Pharmacopeia, this nonproprietary name becomes the drug's official name. Additionally, the manufacturer assigns a proprietary name or trademark, which serves as the brand name under which the drug is marketed. It is worth noting that the same...
Drug Regulation01:25

Drug Regulation

Drug regulation encompasses the management of drug usage by evaluating its safety and efficacy through assessments conducted by regulatory authorities. Regrettably, the history of drug regulation is marred by several catastrophic events. One such incident is the Elixir Sulfanilamide tragedy, in which the toxic compound diethyl glycol was included in a sweet-tasting medication, leading to numerous fatalities. This event prompted the enactment of the Food, Drug, and Cosmetic Act in 1938. Under...
Prescription, Nonprescription and Orphan Drugs01:02

Prescription, Nonprescription and Orphan Drugs

Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
Drug Control Governance: Regulatory Bodies and Their Impact01:03

Drug Control Governance: Regulatory Bodies and Their Impact

Drug control governance involves the oversight and regulation of pharmaceuticals to ensure their safety and efficacy while preventing illegal drug use and trafficking. Regulatory bodies, including the US Food and Drug Administration (FDA) and the European Union's European Medicines Agency (EMA), play a central role in this process. These agencies evaluate the safety and efficacy of drugs before they can be marketed. They fund clinical trials and assess the benefits and risks associated with a...
Drug Products: Biologics, Biosimilars and Interchangeables01:28

Drug Products: Biologics, Biosimilars and Interchangeables

Biologics, derived from living sources such as humans, animals, or microorganisms, represent a significant category of pharmaceuticals. These complex molecules, developed through advanced biotechnological methods or purified from natural sources, include essential medical treatments like insulin and growth hormones. The complexity of biologics arises from their large molecular structures and the intricate processes required for their production, making them distinct from conventional...
Pharmaceutical Equivalents01:26

Pharmaceutical Equivalents

As defined by regulatory standards, pharmaceutical equivalents require generic drug products to have identical dosage forms and chemically identical active pharmaceutical ingredients (APIs). They must adhere to compendial or applicable standards for potency, content uniformity, disintegration times, and dissolution rates. In the case of modified-release dosage forms, variations in drug content are permissible as long as the delivered amount remains consistent with the innovator drug product.

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Articles linked to this work by shared authors, journal, and citation graph.

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Purified components of the Escherichia coli Tat protein transport system form a double-layered ring structure.

European journal of biochemistry·2001
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A naturally occurring bacterial Tat signal peptide lacking one of the 'invariant' arginine residues of the consensus targeting motif.

FEBS letters·2001
Same author

Escherichia coli strains blocked in Tat-dependent protein export exhibit pleiotropic defects in the cell envelope.

Journal of bacteriology·2000
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A novel protein transport system involved in the biogenesis of bacterial electron transfer chains.

Biochimica et biophysica acta·2000
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The twin arginine consensus motif of Tat signal peptides is involved in Sec-independent protein targeting in Escherichia coli.

The Journal of biological chemistry·2000
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TatD is a cytoplasmic protein with DNase activity. No requirement for TatD family proteins in sec-independent protein export.

The Journal of biological chemistry·2000

Related Experiment Video

Updated: Jun 8, 2026

Failure of Cleaning Verification in Pharmaceutical Industry Due to Uncleanliness of Stainless Steel Surface
07:00

Failure of Cleaning Verification in Pharmaceutical Industry Due to Uncleanliness of Stainless Steel Surface

Published on: August 11, 2017

Common road blocks to national accounts pharmaceutical programs.

N R Stanley1

  • 1Pharmaceutical Contracting Services, Doylestown, PA 18901.

Medical Interface
|March 9, 1994
PubMed
Summary

Managed care customers wield significant purchasing power, influencing pharmaceutical product access for large patient populations. Successful national account management requires robust organizational support for contract negotiation and implementation.

Area of Science:

  • Health economics
  • Pharmaceutical market access
  • Managed care strategies

Background:

  • Managed care organizations (MCOs) represent a significant channel for pharmaceutical product distribution.
  • Concentrated purchasing power within MCOs necessitates strategic engagement by pharmaceutical manufacturers.
  • The role of national accounts departments is critical in navigating MCO relationships.

Purpose of the Study:

  • To highlight the importance of managed care customers in the pharmaceutical market.
  • To emphasize the growing significance of contracting in pharmaceutical sales.
  • To underscore the need for organizational support for national accounts departments.

Main Methods:

  • Analysis of market dynamics in pharmaceutical sales.

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  • Review of contracting trends within the managed care sector.
  • Assessment of the operational requirements for national accounts management.

    • Main Results:

    • Managed care customers offer substantial purchasing power and patient access.
    • Contracting agreements are increasingly central to pharmaceutical product distribution.
    • Effective performance of national accounts departments is contingent on organizational backing.

    Conclusions:

    • Pharmaceutical companies must prioritize strategic relationships with managed care customers.
    • Investment in national accounts departments is essential for maximizing market access and contract success.
    • Cross-functional organizational support is vital for the success of pharmaceutical market access initiatives.