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[Hemodynamic changes under metoprolol compared to propranolol in hypertensive patients]
Schweizerische Medizinische Wochenschrift
|November 6, 1976
Summary
Metoprolol effectively lowers renin and heart rate in hypertensive patients. Hemodynamic effects are comparable to propranolol, with a less pronounced impact on cardiac index and blood pressure.
Area of Science:
- Cardiology
- Pharmacology
Background:
- Essential hypertension management often involves beta-blockers.
- Understanding the hemodynamic and renin-modulating effects of new beta-blockers is crucial.
Purpose of the Study:
- To evaluate the effects of metoprolol on hemodynamics and plasma renin activity in patients with essential hypertension.
- To compare metoprolol's effects with those of propranolol.
Main Methods:
- Investigated 5 patients with essential hypertension receiving oral metoprolol (3 X 50 mg/day) at rest and during exercise.
- Measurements taken before, and 4 and 8 weeks after treatment initiation.
- Results compared to 5 propranolol-treated patients matched for age, blood pressure, and renin levels.
Main Results:
- Metoprolol significantly reduced plasma renin activity and heart rate.
- Cardiac index was depressed only during exercise.
- Peripheral resistance was unchanged; left ventricular filling pressure slightly increased.
- Arterial blood pressure showed a slight decrease.
- Compared to propranolol, metoprolol demonstrated similar hemodynamic and renin patterns, with a less pronounced reduction in cardiac index and blood pressure.
Conclusions:
- Metoprolol is effective in reducing renin and heart rate in essential hypertension.
- Its hemodynamic profile is similar to propranolol, offering a potential alternative with a milder impact on cardiac function and blood pressure.