[Compensatory reactions after surgical treatment of peptic ulcer]

The work is based on studies conducted in 30 experimental dogs with gastrointestinal ulcer induced experimentally, which were subjected to selective vagotomy with pyloroplasty after the Heinike--Mikulicz technic, and also in 22 patients having gastric ulcerous disease who were subjected to trunk or selective vagotomy with drainage operations or vagotomy associated with economic gastric resection. As a result of investigation performed, it was found that the operative intervention on the stomach i. e. selective vagotomy with economic gastric resection both experimentally and clinically is accompanied with marked disturbances in the compensatory and adaptation mechanism in the organism, these are manifested in inhibition of oxido-reduction processes (a pronounced decrease in reduced glutathione level, an increase of oxidated glutathione, a great fall in blood vacant oxygen). The postoperative period is characterized by normalization of oxido-reduction processes, their normalization being but slow.