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Formulary conversion from glipizide to glyburide: a cost-minimization analysis.

H L Nadel1

  • 1Bronx Municipal Hospital, NY 10461, USA.

Hospital Pharmacy
|June 1, 1995
PubMed
Summary
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Switching from glipizide to glyburide, an oral hypoglycemic agent, saved costs without impacting glycemic control or safety. This cost-saving strategy proved successful and became a model for other pharmacies.

Area of Science:

  • Pharmacoeconomics
  • Clinical Pharmacy
  • Internal Medicine

Background:

  • Hospitals face economic pressures requiring cost-saving strategies.
  • Formulary substitution is a common approach to reduce medication expenses.

Purpose of the Study:

  • To analyze the cost-minimization of substituting glyburide for glipizide.
  • To evaluate the impact on glycemic control, patient safety, and overall costs.

Main Methods:

  • A cost-minimization analysis was conducted.
  • Prescription records of 76 patients were reviewed.
  • Glycemic control and adverse events were monitored over a 2-year period.

Main Results:

  • Switching from glipizide (19 mg/day) to glyburide (10.2 mg/day) did not affect glycemic control.

Related Experiment Videos

  • A subset of 33 elderly patients had only three drug-related adverse events.
  • A 51% reduction in oral hypoglycemic agent expenditures was achieved.

    • Conclusions:

    • Formulary substitution of glyburide for glipizide is a successful cost-saving strategy.
    • The program demonstrated efficacy in maintaining glycemic control and safety.
    • This model can be adopted by other municipal outpatient pharmacies.