[Bifunctional derivatives of N-nitroso-alkylurea]

Toxic cumulative and antitumor properties of bifunctional N-nitroso-alkylureas as compared with their monofunctional analogues were stuied. Newly produced compounds render a considerable antitumor effect on a number of experimental tumors. A conclusion may be drawn that despite changes in the chemical structure an active metabolic fragment both of mono- and bifunctional compounds is the same, as also evidenced by the cumulation index. However, inspite of a rather high antitumor activity of bifunctional compounds their chemotherapeutic indices are very low.