[Thyrotropic hormone plasma level in thyrotoxicosis]

Immunoreactive TTH plasma concentration was investigated twice a day (at 9 a.m. and 9 p.m.) in 30 patients with thyrotoxicosis, 10 out of them in acute stage and 20 in a state of remission after thymidazol treatment as well as in 17 healthy subjects. The authors established that in the acute state of thyrotoxicosis the latter is reduced to low normal or subnormal values (an average of 2.94 +/- 0.70 ng/ml) and after thyrostatic therapy leading to remission--is about the average norm (4.65 +/- 1.10 ng/ml) and does not differ much from that in healthy subjects (4.75 +/- 0.92 ng/ml). The negative correlation between the TIH levels and thyroid hormones (BOI, total thyroxin), typical for the healthy subjects, is found in the patients with acute thyrotoxicosis. No significant difference was established between the TTH values of the morning and evening hours in any of the groups. The physiological regulatory feedback mechanism in thyrotoxicosis is assumed not to be disturbed.