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Related Experiment Videos

Glucose-sensitive polymeric matrices for controlled drug delivery.

M Goldraich1, J Kost

  • 1Department of Chemical Engineering, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

Clinical Materials
|December 9, 1992
PubMed
Summary

This study developed responsive hydrogels for drug delivery. These glucose-sensitive hydrogels show tunable swelling and release rates, ideal for controlled delivery applications.

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Drug Delivery Systems

Background:

  • Hydrogels are versatile biomaterials with applications in controlled release.
  • Developing stimuli-responsive hydrogels is crucial for advanced drug delivery.
  • Glucose-responsive systems offer potential for precise therapeutic delivery.

Purpose of the Study:

  • To synthesize and characterize novel hydrogel matrices for potential use in drug delivery.
  • To investigate the swelling and release kinetics of hydrogels in response to pH and glucose concentration.
  • To evaluate the enzymatic kinetics of immobilized glucose oxidase within the hydrogel matrix.

Main Methods:

  • Chemical polymerization of 2-hydroxyethyl methacrylate and N,N-dimethyl-aminoethyl methacrylate based monomers.

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  • Incorporation of bioactive molecules like glucose oxidase, bacitracin, or insulin into the hydrogel matrix.
  • Assessment of hydrogel swelling and drug release rates under varying pH and glucose concentrations.
  • Kinetic analysis of soluble and immobilized glucose oxidase activity.

    • Main Results:

    • Hydrogels exhibited accelerated swelling and release rates at lower pH and higher glucose concentrations.
    • Swelling and release kinetics demonstrated responsiveness to physiological glucose concentration changes.
    • The kinetics of both soluble and immobilized glucose oxidase adhered to Michaelis-Menten kinetics.
    • Immobilized enzyme activity was lower than soluble enzyme activity due to mass transfer limitations.

    Conclusions:

    • The developed hydrogels are sensitive to glucose and pH, indicating potential for controlled release applications.
    • Glucose oxidase immobilization within hydrogels follows predictable Michaelis-Menten kinetics.
    • Microbead configurations may enhance immobilized enzyme activity by overcoming mass transfer limitations.