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Liver function tests in the critically ill patient.

P G Roe1

  • 1Addenbrooke's Hospital, Cambridge, UK.

Clinical Intensive Care : International Journal of Critical & Coronary Care Medicine
|December 9, 1992
PubMed
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Liver function tests, including alanine aminotransferase (ALT) and gamma-glutamyl transpeptidase (gammaGT), are crucial for diagnosing liver diseases. Normal levels of these key liver function tests indicate a low likelihood of significant liver damage.

Area of Science:

  • Hepatology
  • Clinical Biochemistry

Background:

  • The liver performs numerous vital functions, susceptible to various diseases.
  • Diagnosis of liver conditions relies on diverse clinical, biochemical, histological, and radiological methods.

Purpose of the Study:

  • To highlight the diagnostic value of specific liver function tests.
  • To explain how key biomarkers reflect distinct aspects of liver health.

Main Methods:

  • Measurement of plasma concentrations of alanine aminotransferase (ALT), gamma-glutamyl transpeptidase (gammaGT), and albumin.
  • Utilizing clinical, biochemical, histological, and radiological assessments for diagnosis.

Main Results:

  • Elevated ALT indicates increased hepatocyte membrane permeability.

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  • Elevated gammaGT suggests cholestasis and toxic liver damage.
  • Reduced albumin levels point to impaired liver protein synthesis.

    • Conclusions:

    • Specific liver function tests are highly valuable for assessing hepatic health.
    • Normal liver function test results significantly reduce the probability of substantial liver disease.