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Green light photodynamic therapy in the human bladder.
U O Nseyo1, D C Merrill, S L Lundahl
1Urology Section, Veterans Administration Medical Center, Martinez, California.
Clinical Laser Monthly
|September 5, 1993
Summary
Green light whole bladder photodynamic therapy (PDT) using Photofrin showed no serious toxicity in a pilot study for bladder cancer. The treatment appears safe at specific laser doses, with toxicity correlating to tumor extent.
Area of Science:
- Oncology
- Photomedicine
- Urology
Background:
- Transitional cell carcinoma is a common bladder cancer.
- Photodynamic therapy (PDT) is an emerging cancer treatment.
- Green light PDT offers a potential therapeutic option.
Purpose of the Study:
- To assess the acute toxicity and safety of green light whole bladder PDT.
- To evaluate the feasibility of this treatment in patients with bladder cancer.
Main Methods:
- Pilot clinical study involving five patients with muscle-invasive bladder cancer.
- Intravenous Photofrin administration followed by green light whole bladder photoactivation.
- Post-treatment evaluation included symptom monitoring, cystometry, and histopathology.
Main Results:
- Acute bladder irritation and volume loss were dose-dependent and related to tumor inflammation.
- No transmural bladder injury or treatment-related morbidity was observed.
- Green light PDT with Photofrin at 20-40 J/cm² demonstrated safety.
Conclusions:
- Green light whole bladder PDT with Photofrin is safe for treating bladder cancer.
- The treatment shows promise with manageable acute toxicity.
- Further studies are warranted to explore efficacy.