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Drug delivery systems.

K Nikander1

  • 1Astra Draco AB, Lund, Sweden.

Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine
|December 9, 1993
PubMed
Summary
This summary is machine-generated.

Comparing nebulizers for inhaled medications, this study found significant differences in drug delivery between solutions and suspensions. Budesonide suspension delivered less drug via ultrasonic nebulizers compared to jet nebulizers in adults.

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Area of Science:

  • Respiratory Medicine
  • Pharmaceutical Technology

Background:

  • Nebulizers convert liquid solutions into aerosols for drug delivery.
  • Recent advancements include nebulized suspensions, necessitating performance comparisons with existing devices.

Purpose of the Study:

  • To compare the inhaled mass of budesonide suspension versus terbutaline solution using jet and ultrasonic nebulizers.
  • To evaluate drug delivery differences between solutions and suspensions in different nebulizer types.

Main Methods:

  • Ex-vivo trials were conducted with adult volunteers and pediatric asthma patients.
  • Dosimetric nebulizers (Spira) were used, with drug output measured on an inserted filter.
  • Nebulizers were operated until 75% of the initial suspension weight was output.

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Main Results:

  • Inhaled drug mass for terbutaline solution was ~50% for both jet and ultrasonic nebulizers.
  • Inhaled budesonide suspension showed ~30% inhaled mass with jet nebulizers and ~10% with ultrasonic nebulizers.
  • Adult data may not directly apply to pediatric populations, necessitating further pediatric studies.

Conclusions:

  • Nebulizer type significantly impacts inhaled drug mass, especially for suspensions like budesonide.
  • Jet nebulizers may be more effective for delivering budesonide suspensions than ultrasonic nebulizers.
  • Further research is needed to determine optimal nebulizer use in pediatric patients.