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Related Experiment Videos

Deposition patterns with Turbuhaler.

L Borgström1

  • 1Astra Draco AB, Lund, Sweden.

Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine
|December 9, 1993
PubMed
Summary

Turbuhaler delivers over 20% of inhaled medication to the lungs at normal flow rates. Lung deposition patterns for terbutaline sulfate and budesonide were similar, regardless of water solubility.

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Area of Science:

  • Pharmacology
  • Respiratory Medicine
  • Drug Delivery Systems

Background:

  • Lung deposition is crucial for evaluating dry powder inhalers.
  • Turbuhaler is a common inhalation device for delivering medications like terbutaline sulfate and budesonide.

Purpose of the Study:

  • To assess lung deposition of terbutaline sulfate and budesonide via Turbuhaler.
  • To compare drug deposition at different inhalation flow rates.
  • To investigate regional drug deposition patterns.

Main Methods:

  • Radioactive and non-radioactive methods were used to measure lung deposition in healthy volunteers.
  • Inhalation flow rates of 60L/min (normal) and 30L/min (low) were tested.
  • Regional deposition was analyzed by calculating the peripheral to central deposition ratio.

Main Results:

  • Mean total lung deposition ranged from 21-32% at normal flow (60L/min) and 15% at low flow (30L/min).
  • Peripheral to central deposition ratios were 2.03 for terbutaline sulfate and 1.72 for budesonide.
  • Both drugs showed similar deposition patterns despite differences in water solubility.

Conclusions:

  • Turbuhaler effectively delivers over 20% of the dose to the lungs at normal inhalation flow.
  • The regional lung deposition pattern is consistent for both water-soluble and non-water-soluble drugs delivered via Turbuhaler.

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