Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Polyurethanes grafted by pendent groups with different sizes and functionality.

S Randrasana1, C Baquey, B Delmond

  • 1INSERM, Bordeaux Cédex, France.

Clinical Materials
|December 9, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Study of two grafting methods for obtaining a 3-aminopropyltriethoxysilane monolayer on silica surface.

Journal of colloid and interface science·2005
Same author

Mineralization of regenerated cellulose hydrogels induced by human bone marrow stromal cells.

European cells & materials·2005
Same author

Development of a resorbable macroporous cellulosic material used as hemostatic in an osseous environment.

Journal of biomedical materials research. Part A·2005
Same author

Biomaterials science: prospects for the new millenium?

Journal of materials science. Materials in medicine·2004
Same author

An in vivo comparative study of the e-polytetrafluoroethylene vascular prostheses: Vitaflon and Gore-Tex.

Journal of materials science. Materials in medicine·2004
Same author

Mineralization of regenerated cellulose hydrogels.

Journal of materials science. Materials in medicine·2004

Grafting alkyl chains onto polyurethanes affects mechanical properties and protein adsorption. Alkyl chains on the backbone weaken properties, while those on the chain extender maintain them, with hexadecyl chains enhancing albumin adsorption.

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Surface Chemistry

Background:

  • Polyurethanes (PUs) are versatile biomaterials, but their surface properties influence biological interactions.
  • Modifying PU backbones or chain extenders can alter mechanical integrity and protein adsorption.
  • Understanding these modifications is crucial for designing PUs with tailored biocompatibility.

Purpose of the Study:

  • To investigate the impact of pendent alkyl chain grafting on polyurethane mechanical properties.
  • To evaluate the in vitro adsorption of albumin and fibrinogen onto modified polyurethanes.
  • To compare the effects of grafting alkyl chains onto the urethane nitrogen versus the chain extender.

Main Methods:

  • Synthesis of polyurethanes with varying alkyl chain lengths (butyl, octyl, decyl, hexadecyl, tetratriacontyl) grafted onto the urethane nitrogen or 1,3-propanediol chain extender.

Related Experiment Videos

  • Mechanical characterization using stress-strain analysis.
  • In vitro adsorption studies using albumin and fibrinogen.

    • Main Results:

    • Grafting alkyl chains onto the urethane nitrogen weakened stress-strain properties.
    • Alkyl chain grafting onto the 1,3-propanediol chain extender maintained high stress-strain properties.
    • The hexadecyl chain resulted in the highest albumin adsorption.
    • Polyurethanes with polyoxyethylene-polyoxypropylene propylsulphonate side chains showed variable protein adsorption based on substitution.

    Conclusions:

    • The location of alkyl chain grafting significantly influences polyurethane mechanical properties.
    • Specific alkyl chain modifications, like hexadecyl grafting, can enhance albumin adsorption.
    • Surface modification strategies offer a means to tune PU interactions with proteins for biomedical applications.