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A mechanical micro spray pump: an alternative to propellant driven devices?

R Jäger-Waldau1, H Mehring, J D Wiggins

  • 1Ing. E. Pfeiffer GmbH & Co. KG, Radolfzell, Germany.

Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine
|December 9, 1993
PubMed
Summary

A new mechanical Micro Spray Pump (MSP) effectively delivers drug solutions to the respiratory tract. In-vitro and in-vivo studies confirm its potential as a propellant-free alternative for respiratory drug delivery.

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Area of Science:

  • Mechanical Engineering
  • Pharmaceutical Sciences
  • Respiratory Medicine

Background:

  • Traditional respiratory drug delivery devices often rely on propellants.
  • There is a need for alternative, propellant-free devices for targeted drug delivery to the lungs.

Purpose of the Study:

  • To develop and evaluate a purely mechanical Micro Spray Pump (MSP) for respiratory drug delivery.
  • To assess the in-vitro and in-vivo deposition characteristics of the MSP.

Main Methods:

  • Development of a mechanical Micro Spray Pump (MSP).
  • In-vitro deposition studies using food dye and salbutamol sulphate solutions with a Twin Impinger.
  • In-vivo studies with a 99mTc-labeled saline solution to assess bronchial deposition.

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Main Results:

  • The MSP demonstrated consistent delivery of aqueous solutions.
  • In-vitro tests showed predictable deposition patterns influenced by dosage and flow rate.
  • In-vivo experiments indicated average bronchial deposition of 8%, with up to 25% in specific cases using a spacer.

Conclusions:

  • The mechanical Micro Spray Pump (MSP) is a viable propellant-free alternative for respiratory drug delivery.
  • The device shows promise for targeted delivery of medications to the respiratory tract.