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Related Experiment Videos

Plasma surface modification of synthetic absorbable sutures.

I H Loh1, H L Lin, C C Chu

  • 1Advanced Surface Technology, Inc., Billerica, Massachusetts.

Journal of Applied Biomaterials : an Official Journal of the Society for Biomaterials
|July 1, 1992
PubMed
Summary

Plasma surface modification is a feasible method to control the degradation rate of synthetic absorbable sutures. This technique improved tensile strength retention in Vicryl and PDSII sutures by increasing hydrophobicity.

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Area of Science:

  • Biomaterials Science
  • Surface Engineering
  • Polymer Chemistry

Background:

  • Synthetic absorbable sutures are widely used in surgery but their degradation rates can be unpredictable.
  • Controlling the hydrolytic degradation rate is crucial for optimizing suture performance and patient outcomes.
  • Current methods for modifying suture properties have limitations.

Purpose of the Study:

  • To investigate the feasibility of using plasma surface modification to alter the hydrolytic degradation rate of commercial synthetic absorbable sutures.
  • To evaluate the impact of different plasma treatments on key suture properties.
  • To identify optimal treatment conditions for enhancing suture performance.

Main Methods:

  • Four types of synthetic absorbable sutures (Dexon, Vicryl, PDSII, Maxon) were surface-modified using parylene deposition and plasma gases (Methane, trimethylsilane, tetrafluoroethene).

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  • Treated sutures underwent in vitro hydrolytic degradation in phosphate buffer (pH 7.4, 37°C) for up to 120 days.
  • Evaluated parameters included tensile breaking strength, weight loss, surface wettability, bending stiffness, and surface morphology.

    • Main Results:

    • Plasma surface treatment proved feasible for modifying suture degradation rates, with effectiveness varying by suture type, treatment, and hydrolysis duration.
    • Vicryl and PDSII sutures demonstrated the most significant improvement in tensile strength retention.
    • Improvements in tensile strength correlated with increased suture hydrophobicity; bending stiffness and surface morphology remained largely unaffected.

    Conclusions:

    • Plasma surface modification offers a promising approach to tailor the degradation characteristics of synthetic absorbable sutures.
    • Further optimization of plasma treatment conditions, including UV shielding, is necessary to maximize benefits.
    • This technology has the potential to enhance the clinical performance of absorbable surgical materials.