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Thrombus deposition on polyurethanes designed for biomedical applications.

H D Wabers1, R W Hergenrother, A J Coury

  • 1Department of Chemical Engineering, University of Wisconsin, Madison 53706.

Journal of Applied Biomaterials : an Official Journal of the Society for Biomaterials
|October 1, 1992
PubMed
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Biomaterials like polyurethanes were tested for blood compatibility. Certain polyurethanes, including ether-free and Pellethane 2363-80A, showed low platelet and fibrinogen deposition, indicating potential for biomedical uses.

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Hemocompatibility Studies

Background:

  • Polyurethanes are widely used in biomedical devices.
  • Assessing their thrombogenicity is crucial for clinical success.
  • Understanding surface properties influences blood-material interactions.

Purpose of the Study:

  • To evaluate the thrombogenicity of six polyurethanes using an ex-vivo canine shunt model.
  • To compare commercial and laboratory-synthesized polyurethanes, including ether-free variants.
  • To investigate the impact of surface characterization techniques and cleaning methods on thrombogenicity.

Main Methods:

  • Ex-vivo canine shunt model with 111In-platelet and 125I-fibrinogen deposition measurements.
  • Surface characterization using static and dynamic contact angle measurements and ESCA.

Related Experiment Videos

  • Acetone extraction to remove extrusion waxes from Pellethane 2363-80A.

    • Main Results:

    • Low deposition of platelets and fibrinogen was observed on ether-free polyurethanes.
    • Pellethane 2363-80A also demonstrated relatively nonthrombogenic surface properties.
    • Surface characterization provided insights into material properties influencing hemocompatibility.

    Conclusions:

    • Ether-free polyurethanes exhibit promising nonthrombogenic characteristics.
    • Pellethane 2363-80A is a suitable candidate for biomedical applications due to its hemocompatibility.
    • These polyurethanes warrant further investigation for use in blood-contacting medical devices.