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Chronic pyelonephritis. An electron microscopic study in nonhuman primates.

T W Smith, J A Roberts

    Investigative Urology
    |September 1, 1978
    PubMed
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    Rhesus monkeys effectively model kidney damage from ascending pyelonephritis. Ultrastructural analysis revealed severe tubular cell injury, particularly in areas with significant inflammation and calyceal dilation.

    Area of Science:

    • Nephrology
    • Veterinary Pathology
    • Microbiology

    Background:

    • Ascending pyelonephritis is a significant kidney infection.
    • Understanding ultrastructural changes is crucial for disease progression.
    • Nonobstructive pyelonephritis presents unique pathological challenges.

    Purpose of the Study:

    • To evaluate the rhesus monkey as a model for studying ascending nonobstructive pyelonephritis.
    • To characterize the ultrastructural changes in the kidney during this condition.

    Main Methods:

    • Utilized rhesus monkeys (Macaca mulatta) for ultrastructural studies.
    • Examined kidney tissue with a focus on inflammatory responses and calyceal morphology.
    • Analyzed renal tubular cells for subcellular alterations.

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    Main Results:

    • Rhesus monkeys served as a successful model for pyelonephritis.
    • Severe kidney damage correlated with inflammatory response intensity and calyceal clubbing.
    • Key ultrastructural findings included swollen mitochondria, dilated endoplasmic reticulum, and basal lamina irregularities in tubular cells.

    Conclusions:

    • The rhesus monkey is a suitable model for investigating pyelonephritis ultrastructure.
    • Ascending nonobstructive pyelonephritis causes distinct tubular cell damage.
    • Further research may explore the absence of visible bacteria in ultrastructural findings.