Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Oxygen delivery and utilization.

D R Dantzker1

  • 1Department of Medicine, Long Island Jewish Medical Center, New Hyde Park, NY 11042.

Applied Cardiopulmonary Pathophysiology : ACP
|December 10, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Monitoring tissue oxygenation : the quest continues.

Chest·2001
Same author

A "closed" medical intensive care unit (MICU) improves resource utilization when compared with an "open" MICU.

American journal of respiratory and critical care medicine·1998
Same author

Primary pulmonary hypertension in a patient with CD8/T-cell large granulocyte leukemia: amelioration by cladribine therapy.

Chest·1997
Same author

Monitoring tissue oxygenation. The search for the grail.

Chest·1997
Same author

Surgery to reduce lung volume.

The New England journal of medicine·1996
Same author

Pulmonary and critical care medicine.

JAMA·1994
Same journal

Closed circuit anesthesia: the man-machine interface.

Applied cardiopulmonary pathophysiology : ACP·1994
Same journal

Monitoring of low flow anesthesia: the United States perspective.

Applied cardiopulmonary pathophysiology : ACP·1994
Same journal

Evaluation of the costs of anesthesia gases.

Applied cardiopulmonary pathophysiology : ACP·1994
Same journal

An analysis of costs of closed circuit anesthesia in Italy (January-June 1992).

Applied cardiopulmonary pathophysiology : ACP·1994
Same journal

Closed circuit anesthesia: preservation of the environment.

Applied cardiopulmonary pathophysiology : ACP·1994
Same journal

Xenon anesthesia: prerequisite for its use in a closed circuit system.

Applied cardiopulmonary pathophysiology : ACP·1994
See all related articles

Oxygen transport is regulated to meet metabolic demands. In critical illness, impaired oxygen extraction contributes to organ failure, even with increased oxygen delivery.

Area of Science:

  • Physiology
  • Critical Care Medicine

Background:

  • Oxygen transport (TO 2) is crucial for meeting metabolic demands via oxidative phosphorylation (VO 2).
  • Normally, increased VO 2 is met by augmenting TO 2 and increasing oxygen extraction ratio (O 2ER).
  • In experimental animals, VO 2 declines when O 2ER exceeds 0.50, indicating a critical TO 2 level (TO 2crit).

Purpose of the Study:

  • To investigate the oxygen transport and utilization abnormalities in patients with sepsis and adult respiratory distress syndrome (ARDS).
  • To determine if these critically ill patients can increase their O 2ER when oxygen delivery is reduced.

Main Methods:

  • The study focuses on the physiological regulation of oxygen transport and extraction.
  • Compares oxygen transport dynamics in normal subjects versus patients with sepsis and ARDS.

Related Experiment Videos

Main Results:

  • Patients with sepsis and ARDS exhibit impaired oxygen extraction and utilization.
  • Despite often higher than normal TO 2, these patients commonly develop lactic acidosis.
  • When TO 2 is reduced, patients with sepsis and ARDS cannot increase their O 2ER above the normal resting value of 0.33.

Conclusions:

  • Sepsis and ARDS are associated with an inability to adequately extract and utilize delivered oxygen.
  • This impaired oxygen utilization contributes to organ failure and high mortality in these conditions.
  • The inability to increase O 2ER suggests a critical limitation in oxygen delivery or cellular oxygen utilization.