Related Experiment Video
Updated: Jul 31, 2026
Biological Compatibility Profile on Biomaterials for Bone Regeneration
Published on: November 16, 2018
Initial in-vivo evaluation of glass-ionomer cements for use as alveolar bone substitutes
I M Brook1, G T Craig, D J Lamb
1School of Clinical Dentistry, University of Sheffield, South Yorkshire, UK.
Abstract:
The response of rat femora to implantation of four glass-ionomer (polyalkenoic) cements (GIC) compared to that seen following implantation of densely sintered hydroxyapatite (Ha) ceramic was evaluated for periods up to 12 weeks. Light and transmission electron microscopic analysis of the GIC/bone interface revealed direct bonding of the GIC G338 and Ketac Cem (both based on fluoro-alumino-silicate) glasses to bone, with a mineralized collagen-containing extra-cellular matrix deposited on the surface of the GIC. AquaCem and the fluoride-free GIC based on MP4 glass showed incomplete osseointegration.
