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Related Experiment Videos

Comparative physical tests on segmented polyurethanes for cardiovascular applications.

M C Tanzi1, L Ambrosio, L Nicolais

  • 1Department of Bioingegneria, Politecnico di Milano, Italy.

Clinical Materials
|December 10, 1990
PubMed
Summary
This summary is machine-generated.

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This study evaluated five biomedical polyurethanes for cardiovascular prostheses. While hydrolytic testing revealed molecular weight degradation in most, key mechanical and thermal properties remained stable, preventing a clear material selection.

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Cardiovascular Engineering

Background:

  • Segmented polyurethanes (SPUs) are crucial for cardiovascular prostheses.
  • Selecting the optimal SPU requires rigorous physical and chemical characterization.
  • Biomedical polyurethanes undergo various stresses in vivo, necessitating evaluation of their stability.

Purpose of the Study:

  • To evaluate and compare the physical properties of five commercially available biomedical segmented polyurethanes (SPUs).
  • To assess the hydrolytic stability and its impact on the mechanical and thermal properties of these SPUs.
  • To identify a suitable SPU candidate for cardiovascular prosthesis applications.

Main Methods:

  • Solvent casting of SPU sheets (0.2-0.3 mm) from THF or DMAC.

Related Experiment Videos

  • Tensile mechanical testing at 23°C and 37°C.
  • Hydrolytic stability testing in water and alkaline buffer at elevated temperatures (37-85°C) for 96-168 hours.
  • Gel permeation chromatography (GPC) for molecular weight analysis.
  • Differential scanning calorimetry (DSC) and dynamic mechanical analysis (DMA) for thermal and mechanical properties.
  • Scanning electron microscopy (SEM) for morphological analysis.

    • Main Results:

    • All SPUs exhibited typical elastomeric stress/strain behavior with minor differences.
    • Hydrolytic testing generally led to molecular weight degradation (Mw), particularly after prolonged exposure.
    • Tensile, thermal, and dynamic mechanical properties remained largely unaffected by hydrolytic exposure.
    • Morphological changes due to degradation were observed only in Biomer via SEM and thermomechanical analysis.

    Conclusions:

    • None of the five investigated biomedical polyurethanes could be definitively selected based on initial physical and hydrolytic stability tests.
    • While molecular weight decreased, critical material properties essential for cardiovascular prostheses were largely maintained across most tested SPUs.
    • Further investigation into long-term performance and specific application requirements is needed for definitive SPU selection.