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Related Experiment Videos

Development of small-diameter vascular prostheses which release bioactive agents.

G Soldani1, M Steiner, P M Galletti

  • 1Artificial Organ Laboratory, Brown University, Providence, Rhode Island 02912.

Clinical Materials
|December 10, 1990
PubMed
Summary

Researchers developed a new bioactive vascular prosthesis using albumin and basic Fibroblast Growth Factor (bFGF). This porous membrane shows potential for small-diameter blood vessel repair, releasing growth factors over two weeks.

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Small-diameter vascular prostheses are crucial for treating cardiovascular diseases.
  • Developing bioactive materials that promote healing and integration is a key challenge.
  • Incorporating growth factors like basic Fibroblast Growth Factor (bFGF) can enhance tissue regeneration.

Purpose of the Study:

  • To fabricate a novel bioactive small-diameter vascular prosthesis.
  • To incorporate albumin and basic Fibroblast Growth Factor (bFGF) into a porous membrane.
  • To evaluate the material's structure, drug release kinetics, and biological activity.

Main Methods:

  • Fabrication using a combined spraying and phase-inversion technique.
  • Utilizing a polyetherurethane-urea (Biomer) solution with albumin and bFGF in dimethylacetamide (DMA).

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  • Characterization via Scanning Electron Microscopy (SEM) and in-vitro cell proliferation assays.

    • Main Results:

    • A porous, distensible, tubular membrane with an open-cell trabecular structure was successfully fabricated.
    • Albumin and bFGF particles were observed entrapped within the polyurethane matrix.
    • Sustained release of albumin and bFGF for over 2 weeks was achieved.
    • Incorporated bFGF retained biological activity, promoting human endothelial cell proliferation.

    Conclusions:

    • The developed material shows promise as a bioactive small-diameter vascular prosthesis.
    • The fabrication method allows for controlled incorporation and release of therapeutic agents.
    • The bioactive nature of the prosthesis supports potential for enhanced vascular tissue regeneration.