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Published on: May 28, 2010
Echocardiography of dilated cardiomyopathy in children
1Department of Pediatrics and Adolescents, St. Louis University School of Medicine, Missouri.
Insights
Echocardiography effectively diagnoses and manages pediatric dilated cardiomyopathy. M-mode and 2D echocardiography assess left ventricular function and structure, with low shortening fraction indicating poor prognosis.
Area of Science:
- Pediatric Cardiology
- Diagnostic Imaging
Background:
- Dilated cardiomyopathy (DCM) in children presents diagnostic challenges.
- Echocardiography is a key non-invasive tool for cardiac assessment.
Purpose of the Study:
- To evaluate the utility of echocardiography in diagnosing and managing pediatric dilated cardiomyopathy.
- To identify echocardiographic parameters indicative of disease severity and prognosis.
Main Methods:
- M-mode echocardiography for quantitative assessment of left ventricular (LV) and left atrial dimensions, wall thickness, and systolic function (e.g., shortening fraction, V cf).
- Two-dimensional echocardiography for evaluating structural abnormalities, excluding valvular or coronary anomalies, and detecting thrombi.
Main Results:
- LV and left atrial dimensions are typically enlarged (1.5x normal).
- Markedly reduced LV systolic function is observed, with shortening fraction being a crucial severity index.
- A very low shortening fraction (12-15%) at presentation and follow-up signifies a poor prognosis.
- Two-dimensional echocardiography aids in identifying LV free wall involvement over the septum and ruling out other cardiac pathologies.
Conclusions:
- Echocardiography, encompassing both M-mode and 2D techniques, is a reliable method for the diagnosis and management of pediatric dilated cardiomyopathy.
- Echocardiographic parameters, particularly shortening fraction, are vital for assessing disease severity and predicting outcomes in affected children.
Abstract:
Echocardiography is useful and reliable in the diagnosis and management of children with dilated cardiomyopathy. M-mode echocardiography provides quantitative information of left ventricular and left atrial dimensions and left ventricular wall thickness. Left ventricular function including shortening fraction, mean velocity of circumferential fiber shortening (V cf), systolic time intervals, left ventricular wall thickening and thinning rate, isovolumic contraction time, and wall stress can be derived from M-mode study. Left ventricular and left atrial dimensions are usually 1.5 times normal. Left ventricular systolic function is markedly reduced. Shortening fraction can be easily obtained and is the most informative index for assessing the severity of illness. Very low shortening fraction at presentation and follow-up (12-15%) is a poor prognostic sign. Two-dimensional echocardiography is valuable for excluding valvular lesion or coronary artery anomaly and detection of intracardiac thrombus. The left ventricular free wall is usually more severely affected than the ventricular septum as seen by two-dimensional echocardiography.
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