Related Experiment Video
Updated: Aug 10, 2026

Detecting Somatic Genetic Alterations in Tumor Specimens by Exon Capture and Massively Parallel Sequencing
Published on: October 19, 2013
Molecular genetics diagnostic applications in oncology
1The University of Texas M.D. Anderson Cancer Center, Hematopathology Program, Houston 77030.
Abstract:
The use of lineage and cytogenetic probes in diagnosis of oncologic disorders is reviewed. The presence of rearranged bands via Southern blot analysis may generate diagnostic support of hematopoietic malignancy in several instances. DNA probes can be used to demonstrate clonality, reveal lineage characteristics, or identify specific chromosomal aberrations. Lineage probes detect genetic events during normal lymphocyte differentiation, while cytogenetic probes detect a malignant characteristic. The number of translocations detectable using DNA probes will likely expand in the future.
More Related Videos
Related Concept Videos
Cancer
Tumor Progression
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Targeted Cancer Therapies
There are several types of targeted therapies against specific...
Combination Therapies and Personalized Medicine
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Modern Molecular Taxonomy
Applications of Molecular Taxonomy

