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A light-diffusing device for intraoperative photodynamic therapy in the peritoneal or pleural cavity
T F DeLaney1, P D Smith, G F Thomas
1Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Journal of Clinical Laser Medicine & Surgery
|October 1, 1991
Summary
This study presents an inexpensive, modified endotracheal tube device for effective intraoperative photodynamic therapy (PDT). The device ensures homogeneous light delivery to complex tumor surfaces in the peritoneal and pleural cavities.
Area of Science:
- Medical Devices
- Oncology
- Photodynamic Therapy
Background:
- Effective photodynamic therapy (PDT) relies on precise light delivery to tumor sites.
- Illuminating complex anatomical surfaces like the peritoneal and pleural cavities presents a significant challenge in PDT.
Purpose of the Study:
- To describe a novel, inexpensive light-diffusing device for intraoperative PDT.
- To evaluate the efficacy and reliability of this device for illuminating tumor-involved cavities.
Main Methods:
- Modification of readily available endotracheal tubes into a light-diffusing device.
- Intraoperative use in over 50 patients with tumors in the peritoneal and pleural cavities.
- Combination with a lipid-based diffusing medium and real-time power/energy density monitoring.
Main Results:
- The modified endotracheal tube device facilitated homogeneous illumination of complex cavity surfaces.
- The device demonstrated a high degree of reliability, with no reported failures in over 50 patient cases.
- Successful intraoperative PDT delivery was achieved using the described system.
Conclusions:
- The developed light-diffusing device is a cost-effective and reliable tool for intraoperative PDT.
- This approach enables homogeneous light delivery, crucial for effective treatment of surface tumors in challenging anatomical locations.
- The system offers a practical solution for enhancing PDT efficacy in oncological applications.