Related Experiment Videos
In vitro evaluation of a new dual screen microaggregate filter
P A Napychank1, W McDonough, T L Simon
1Department of Laboratory Medicine, Yale University School of Medicine, New Haven, Connecticut.
Transfusion Science
|December 10, 1990
Summary
A new dual screen microaggregate filter offers comparable performance to existing filters for blood products. Its high flow rate makes it suitable for massive transfusion protocols in critical care settings.
Area of Science:
- Biomedical Engineering
- Transfusion Medicine
Background:
- Microaggregate filters are crucial in blood transfusions to remove harmful particles.
- Existing filters have limitations in flow rate and capacity.
Purpose of the Study:
- To evaluate a new second-generation 40/150 µm dual screen microaggregate filter.
- To compare its performance against a standard 40 µm filter.
Main Methods:
- Comparative analysis of filter flow rate, capacity, and removal efficiency for microaggregates and leukocytes.
- Assessment of filtration-induced hemolysis and impact on stored platelet concentrates.
Main Results:
- The new 40/150 µm filter demonstrated comparable microaggregate and leukocyte removal to the control filter.
- Mean flow rates of 45 g/min were achieved, suitable for massive transfusion.
- Filtration of red blood cells and platelet concentrates showed comparable results.
Conclusions:
- The second-generation 40/150 µm dual screen filter is effective for clinical transfusion.
- Its high flow rate supports its use in massive transfusion scenarios like trauma care.