Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Peripheral nerve repair with collagen conduits.

S T Li1, S J Archibald, C Krarup

  • 1Colla-Tec, Inc., Plainsboro, New Jersey 08536.

Clinical Materials
|December 10, 1991
PubMed
Summary

This study developed a semipermeable collagen conduit for peripheral nerve repair, showing effective regeneration and functional recovery comparable to nerve autografts in primate models.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Analysis of the contamination characteristics and pathogenic potential of <i>Listeria monocytogenes</i> in pre-packaged and refrigerated ready-to-eat cooked meat products in Chengdu City].

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]·2025
Same author

[Cognitive function status and its correlation with blood pressure control in patients with hypertension in China].

Zhonghua xin xue guan bing za zhi·2024
Same author

Mapping Out Remediation: An Actionable Roadmap to Support Trainees Through Remediation.

Academic pediatrics·2024
Same author

[Antimicrobial resistance and genomic characterization of <i>Campylobacter</i> isolates recovered from retailed poultry meat samples in 20 provinces of China in 2020].

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]·2024
Same author

[Catheter ablation technologies for persistent atrial fibrillation: controversies and evaluation].

Zhonghua xin xue guan bing za zhi·2023
Same author

[Analysis of factors associated with anxiety in patients with atrial fibrillation and their caregivers].

Zhonghua yi xue za zhi·2023

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Neuroscience

Background:

  • Peripheral nerve injuries often require surgical repair, with nerve autografts being the current standard but having limitations.
  • Developing artificial conduits for nerve regeneration is crucial for overcoming donor site morbidity and graft availability issues.

Purpose of the Study:

  • To evaluate a novel semipermeable collagen conduit for peripheral nerve repair.
  • To assess the conduit's biocompatibility, nutrient exchange capabilities, and efficacy in promoting nerve regeneration and functional recovery.

Main Methods:

  • Fabrication of a semipermeable tubular collagen matrix.
  • In-vitro assessment of molecular diffusion (e.g., bovine serum albumin) and cross-linking for controlled resorption.
  • In-vivo studies in primates to compare conduit performance against nerve autografts, evaluating motor and sensory recovery.

Main Results:

  • The semipermeable collagen conduit demonstrated rapid diffusion of large molecules, indicating effective nutrient and factor exchange.
  • In-vitro studies confirmed adequate cross-linking for controlled in-vivo biodegradation.
  • Primate studies showed comparable physiological recovery of motor and sensory functions between the collagen conduit and nerve autografts.

Conclusions:

  • The developed semipermeable collagen conduit shows significant promise as an effective off-the-shelf prosthesis for peripheral nerve repair.
  • This biomaterial represents a viable alternative to nerve autografts, potentially simplifying clinical procedures and improving patient outcomes.

Related Experiment Videos