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Human osteoblast response to PTFE surfaces.

W R Walsh1, M Olmedo, H D Kim

  • 1Department of Orthopaedics, Brown University, Rhode Island Hospital, Providence 02903, USA.

Clinical Materials
|December 9, 1993
PubMed
Summary
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Expanded polytetrafluoroethylene (ePTFE) grafts do not support human osteoblast growth for wrist surgery. While ePTFE may serve as a space filler in carpal bone arthroplasties, further material development is needed for better cell interaction.

Area of Science:

  • Biomaterials Science
  • Orthopedic Surgery
  • Cell Biology

Background:

  • Expanded polytetrafluoroethylene (ePTFE) is used in vascular grafts for carpal bone interpositional arthroplasties.
  • Limited data exist on human osteoblast response to ePTFE in this application.

Purpose of the Study:

  • To investigate the morphological and mitogenic effects of vascular-grade ePTFE on human osteoblasts in vitro.
  • To assess the suitability of ePTFE for carpal bone arthroplasties based on cell interactions.

Main Methods:

  • In-vitro cell culture of human osteoblasts on ePTFE vascular grafts.
  • Evaluation of cell morphology and proliferation on ePTFE surfaces.

Main Results:

  • Neither the inner nor the outer surface of ePTFE supported osteoblast growth.

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  • ePTFE did not demonstrate mitogenic effects on human bone cells.

    • Conclusions:

    • Current ePTFE vascular grafts are not ideal for promoting osteoblast growth in carpal bone arthroplasties.
    • Polytetrafluoroethylene (PTFE) might be suitable as a space filler, but modifications are needed for enhanced osteoblast support.