Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Resorbable synthetic polymers as replacements for bone graft.

A G Coombes1, M C Meikle

  • 1Department of Pharmaceutical Sciences, University of Nottingham, University Park, UK.

Clinical Materials
|December 9, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Engineering three-dimensional constructs of the periodontal ligament in hyaluronan-gelatin hydrogel films and a mechanically active environment.

Journal of periodontal research·2013
Same author

The effect of cyclic mechanical strain on the expression of adhesion-related genes by periodontal ligament cells in two-dimensional culture.

Journal of periodontal research·2011
Same author

Osteogenic gene expression by human periodontal ligament cells under cyclic tension.

Journal of dental research·2007
Same author

On the transplantation, regeneration and induction of bone: the path to bone morphogenetic proteins and other skeletal growth factors.

The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·2007
Same author

Remodeling the dentofacial skeleton: the biological basis of orthodontics and dentofacial orthopedics.

Journal of dental research·2006
Same author

The evolution of plastic and maxillofacial surgery in the twentieth century: the Dunedin connection.

The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·2006

Resorbable synthetic polymers like poly(lactide) and poly(glycolide) show promise as bone graft substitutes. Optimizing polymer properties and implant design is crucial for effective bone healing and regeneration.

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Orthopedic Surgery

Background:

  • Resorbable synthetic polymers, particularly poly(alpha-hydroxy acids) like poly(lactide) and poly(glycolide), are being investigated as bone graft substitutes.
  • Understanding the interplay between polymer synthesis, degradation, and implant performance is essential for successful clinical application.

Purpose of the Study:

  • To review the potential of resorbable synthetic polymers as bone graft substitutes.
  • To define the relationship between polymer characteristics, implant properties, and degradation behavior.
  • To highlight key considerations for the design and manufacturing of polymeric bone implants.

Main Methods:

  • Literature review of resorbable synthetic polymers for bone applications.

Related Experiment Videos

  • Analysis of factors influencing polymer degradation: synthesis, chain structure, morphology, processing, and dimensions.
  • Evaluation of implant dimensional stability during early bone healing stages.

    • Main Results:

    • The degradation behavior of resorbable implants is closely linked to polymer synthesis, chain structure, implant morphology, processing, and dimensions.
    • Extensive documentation exists for the production of resorbable polymeric implants, offering diverse manufacturing options.
    • Maintaining implant dimensional stability during early bone healing is critical for osteoblast migration and bone matrix deposition.

    Conclusions:

    • Minimizing the content of slow-resorbing polymers like poly(L-lactide) is recommended while ensuring adequate degradation characteristics.
    • Alternative resorbable polymers, such as polyphosphazines, are emerging as promising candidates for bone repair and reconstruction.
    • Careful selection of polymer properties and implant design is vital for optimizing bone regeneration outcomes.