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Related Experiment Videos

Evaluation of a rapid infusion system.

R Cronbaugh1, J Ploessl, R Sutton

  • 1Department of Surgery, University of Iowa Hospitals and Clinics Iowa City, USA.

The Journal of Extra-Corporeal Technology
|November 4, 1994
PubMed
Summary

This study evaluated a rapid infusion system for blood products during surgery. The system effectively warmed and recirculated blood for hours with minimal adverse effects on key parameters.

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Area of Science:

  • Cardiovascular Surgery
  • Transfusion Medicine
  • Biomedical Engineering

Background:

  • Massive blood loss during surgery necessitates rapid warming and transfusion of blood products.
  • Existing systems may not adequately meet the demands for rapid, large-volume blood warming and infusion.

Purpose of the Study:

  • To evaluate the effects of warming and extended recirculation on blood products using an in-house rapid infusion system.
  • To assess the safety and efficacy of a novel system for managing blood products in high-loss surgical scenarios.

Main Methods:

  • Assembled a recirculating rapid infusion system with cardiotomy reservoirs, centrifugal pump, and heat exchanger.
  • Applied the system in six adult orthotopic liver transplantations, priming with fresh frozen plasma and packed red blood cells.

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  • Monitored blood gases, oxygen saturation, hematocrit, plasma free hemoglobin, sodium, and potassium levels over time.

    • Main Results:

    • No significant changes observed in pH, pO2, pCO2, hematocrit, or plasma free hemoglobin after 3 hours of recirculation.
    • Significant decrease in potassium levels (11.6 to 10.0 meq/L) and significant increase in sodium levels (144 to 147 meq/L).
    • Significant increase in oxygen saturation (59% to 70%) following recirculation.

    Conclusions:

    • The developed recirculating rapid infusion system can safely warm and maintain blood products for extended periods during surgery.
    • The system demonstrates potential for improving blood product management in procedures with high transfusion requirements.
    • Further investigation into electrolyte shifts and oxygen saturation changes is warranted.