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Related Experiment Video

Updated: Jul 14, 2026

Novel Percutaneous Approach for Deployment of 3D Printed Coronary Stenosis Implants in Swine Models of Ischemic Heart Disease
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Laser angioplasty in miniature swine: advantages of a modified fiber tip delivery system.

C J White1, S R Ramee, G Samson

  • 1Department of Internal Medicine, Ochsner Medical Institutions, New Orleans, Louisiana.

Journal of Interventional Cardiology
|December 10, 1990
PubMed
Summary

A new lensed fiber laser angioplasty device improved artery recanalization rates and reduced perforations compared to bare fiber methods in swine models. This atraumatic lensed fiber is safer and more effective for occlusive lesions.

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Area of Science:

  • Cardiovascular Interventions
  • Biomedical Engineering
  • Laser Medicine

Background:

  • Atherosclerotic iliac artery occlusion presents a significant clinical challenge.
  • Current laser angioplasty techniques using bare fiber tips have limitations in efficacy and safety.
  • Minimally invasive treatments are crucial for managing peripheral artery disease.

Purpose of the Study:

  • To compare the effectiveness and safety of a novel spherical lensed fiber-tip laser delivery catheter versus a bare silica fiber tip for laser angioplasty.
  • To evaluate recanalization success rates and incidence of vascular perforation in occluded atherosclerotic arteries.

Main Methods:

  • Laser angioplasty was performed in miniature swine with occluded iliac arteries.
  • Two groups were studied: Group I (bare silica fiber, n=11 arteries) and Group II (spherical lensed fiber tip, n=41 arteries).

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  • An argon ion laser (2-3 watts, 1-5 second intervals) was used for in vivo treatment.

    • Main Results:

    • Successful recanalization was achieved in 64% of arteries in Group I versus 85% in Group II.
    • Vascular perforation occurred in 36% of arteries in Group I compared to 10% in Group II (P < 0.05).
    • Mechanical perforation by the bare fiber accounted for 50% of perforations in Group I, with none in Group II.

    Conclusions:

    • The atraumatic lensed fiber delivery system is more effective for recanalizing occlusive atherosclerotic lesions.
    • The lensed fiber represents a safer alternative to bare silica fiber delivery systems, significantly reducing vascular perforation rates.
    • This technology holds promise for improving outcomes in laser angioplasty procedures.