Meptazinol: I.M. use in postoperative pain

Area of Science:

• Pharmacology
• Anesthesiology
• Pain Management

Background:

• Postoperative pain management is crucial for patient recovery.
• Evaluating novel analgesics for efficacy and safety is an ongoing need.

Purpose of the Study:

• To assess the efficacy and safety of Meptazinol as a postoperative analgesic.
• To determine the onset, duration, and patient-reported effectiveness of Meptazinol.

Main Methods:

• A study involving 39 patients in the postoperative period.
• Meptazinol administered intramuscularly at 100 mg, on patient request.
• Monitoring of cardiovascular and respiratory parameters.
• Evaluation of analgesia by anesthetists and nurses.

Main Results:

• Significant cardiovascular and respiratory stability observed.
• Rapid onset of analgesia within approximately 15 minutes.
• Peak analgesia achieved around 30 minutes.
• Good analgesia lasted for about 2 hours.
• Patients requested a subsequent dose after approximately 5 hours.

Conclusions:

• Meptazinol demonstrates rapid onset and effective duration for postoperative pain relief.
• The drug appears safe, with no significant adverse effects on vital signs.
• Meptazinol offers a promising option for patient-controlled postoperative analgesia.