Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Polycythemia vera in an anephric man.

J L Spivak, C R Cooke

    The American Journal of the Medical Sciences
    |November 1, 1976
    PubMed
    Summary

    In polycythemia vera, erythropoiesis, the production of red blood cells, does not depend on erythropoietin. This study observed a patient with polycythemia vera undergoing renal failure and nephrectomy.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The polycythemia vera stem cell.

    Leukemia supplements·2016
    Same author

    Patterns of injury in mycophenolate mofetil-related colitis.

    Transplantation proceedings·2010
    Same author

    Automatic laser tracking and ranging system.

    Applied optics·2010
    Same author

    The quantitative JAK2 V617F neutrophil allele burden does not correlate with thrombotic risk in essential thrombocytosis.

    Leukemia·2007
    Same author

    The third International Congress on Myeloproliferative and Myelodysplastic Syndromes.

    Leukemia research·2006
    Same author

    Cirrhosis and IgA nephropathy related to the PiSZ phenotype of alpha1-antitrypsin deficiency.

    Clinical nephrology·2005

    Area of Science:

    • Hematology
    • Nephrology
    • Oncology

    Background:

    • Polycythemia vera is a myeloproliferative neoplasm characterized by excessive red blood cell production.
    • The role of erythropoietin in erythropoiesis is well-established, but its necessity in polycythemia vera remained unclear.
    • Renal function significantly impacts erythropoiesis through erythropoietin production.

    Observation:

    • A patient with polycythemia vera maintained a high hematocrit despite renal failure and bilateral nephrectomy.
    • Erythropoietin was undetectable in plasma before and after nephrectomy.
    • The patient's bone marrow cells did not respond to erythropoietin in vitro.

    Findings:

    • Erythropoiesis in this patient with polycythemia vera occurred independently of detectable erythropoietin.
    • Renal failure and nephrectomy did not abolish red blood cell production in the context of polycythemia vera.
    • Iron supplementation demonstrated a capacity to restore hematocrit levels.

    Implications:

    • This suggests an alternative mechanism for erythropoiesis in polycythemia vera, independent of erythropoietin.
    • Understanding these alternative pathways could lead to novel therapeutic strategies for polycythemia vera.
    • The study challenges the universal requirement of erythropoietin for red blood cell production in certain hematological conditions.

    Related Experiment Videos