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Making PVC more biocompatible.

¹Cardiovascular Division of Biocompatibles Ltd., Uxbridge, UK.

Medical Device Technology

|August 6, 1995

Summary

Coating medical devices like poly(vinyl chloride) with synthetic phosphorylcholine polymers improves biocompatibility. This biomimetic approach reduces adverse reactions and thrombus formation, enhancing material safety for medical applications.

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Area of Science:

Biomaterials Science
Polymer Chemistry
Biomedical Engineering

Background:

Poly(vinyl chloride) (PVC) is widely used for disposable medical devices.
PVC can cause adverse reactions and thrombus formation upon contact with biological systems.
Existing materials often lack sufficient biocompatibility for critical medical applications.

Purpose of the Study:

To enhance the biocompatibility of materials, particularly PVC, for medical device applications.
To investigate the use of synthetic phosphorylcholine-containing polymers as surface coatings.
To mimic the natural cell membrane's outer surface for improved biological interaction.

Main Methods:

Surface modification of materials using phosphorylcholine-containing polymers.
Evaluation of material-tissue and material-fluid interactions.
Assessment of biocompatibility through experimental evidence.

Main Results:

The proposed coating strategy effectively mimics the cell membrane surface.
Enhanced biocompatibility of PVC and other materials was demonstrated.
Reduction in adverse biological responses and thrombus formation was observed.

Conclusions:

Synthetic phosphorylcholine coatings offer a promising approach to improve the biocompatibility of medical devices.
This biomimetic strategy addresses key limitations of conventional materials like PVC.
The findings support the broader application of these coatings in medical technology.

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