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Related Experiment Videos

Cephalosporin utilisation review and evaluation.

G M Misan1, C Dollman, D R Shaw

  • 1Pharmacy Department, Royal Adelaide Hospital, Australia.

Pharmacoeconomics
|July 7, 1995
PubMed
Summary

Drug utilization reviews (DUR) for cephalosporins improve antibiotic prescribing and reduce healthcare costs. These interventions did not negatively impact patient outcomes or safety, demonstrating a model for rational antibiotic therapy.

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Area of Science:

  • Pharmacoeconomics
  • Infectious Diseases
  • Clinical Pharmacy

Background:

  • Clinical drug misuse leads to patient harm, increased healthcare costs, and resource wastage.
  • Drug utilization evaluation (DUE) identifies inappropriate drug use and promotes rational therapy.
  • Antibiotics are frequently targeted for DUE due to misuse, antimicrobial resistance, and escalating expenditures.

Purpose of the Study:

  • To evaluate the effectiveness of cephalosporin drug utilization evaluation (DUE) in modifying prescribing patterns and controlling costs.
  • To assess the impact of interventions on post-operative infection rates, clinical outcomes, and adverse drug reactions.

Main Methods:

  • Review of studies on cephalosporin DUE, including isolated projects and ongoing programs.
  • Implementation of audit criteria based on understanding infectious processes, anti-infective pharmacology, and clinical monitoring.

Related Experiment Videos

  • Investigation of cephalosporin use (e.g., ceftriaxone, ceftazidime, cefoxitin) through a DUE program at Royal Adelaide Hospital.

    • Main Results:

    • Cephalosporin DUE successfully modified cephalosporin use and contained drug expenditure.
    • Reviews at Royal Adelaide Hospital led to improved cephalosporin use and significant cost savings.
    • Recommended alterations in cephalosporin use did not adversely affect post-operative infection rates, clinical outcomes, or adverse drug reactions.

    Conclusions:

    • Cephalosporin DUE is an effective strategy for promoting rational and economical antibiotic therapy.
    • The experience provides a useful model for optimizing the use of cephalosporins and other drug classes.
    • Interventions can improve drug utilization and reduce costs without compromising patient safety or clinical outcomes.