Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Perfluorochemical-based artificial oxygen carrying red cell substitutes.

T A Lane1

  • 1Department of Pathology 0612, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.

Transfusion Science
|February 7, 1995
PubMed
Summary

Perfluorochemical emulsions (PFE) show promise as artificial oxygen carriers but require further trials to ensure safety and efficacy. Second-generation PFEs offer improved oxygen delivery and stability for various medical applications.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A systematic review of calcium channel antagonists in bipolar disorder and some considerations for their future development.

Molecular psychiatry·2016
Same author

The group II metabotropic glutamate receptor 3 (mGluR3, mGlu3, GRM3): expression, function and involvement in schizophrenia.

Journal of psychopharmacology (Oxford, England)·2008
Same author

CTLA-4 blockade by a human MAb enhances the capacity of AML-derived DC to induce T-cell responses against AML cells in an autologous culture system.

Cytotherapy·2006
Same author

Improving the efficiency of PBPC collection by pre-apheresis peripheral blood and mid-apheresis product measurements of CD34 cells.

Cytotherapy·2005
Same author

Simultaneous administration of G-CSF and GM-CSF for re-mobilization in patients with inadequate initial progenitor cell collections for autologous transplantation.

Cytotherapy·2002
Same author

Leukocyte-reduced red blood cell transfusions in patients with anemia and human immunodeficiency virus infection: the Viral Activation Transfusion Study: a randomized controlled trial.

JAMA·2001

Area of Science:

  • Biomedical Engineering
  • Hematology
  • Resuscitation Medicine

Background:

  • Perfluorochemical emulsions (PFE) are being developed as artificial oxygen carriers.
  • Current PFEs face challenges with adverse effects and demonstrated efficacy in human trials.
  • First-generation products like Fluosol-DATM had limited success due to side effects and efficacy issues.

Purpose of the Study:

  • To review the progress and challenges in the development of PFE-based artificial oxygen carriers.
  • To evaluate the potential of second-generation PFE, such as Oxygent-HTTM, for improved oxygen delivery.
  • To explore diverse clinical applications of PFEs beyond oxygen transport.

Main Methods:

  • Review of existing research and clinical trial data on perfluorochemical emulsions.

Related Experiment Videos

  • Comparison of first-generation and second-generation PFE characteristics and performance.
  • Analysis of potential applications including organ perfusion, tumor oxygenation, and liquid ventilation.

    • Main Results:

    • Second-generation PFEs demonstrate enhanced oxygen-carrying capacity and stability compared to earlier versions.
    • Initial trials of newer PFEs reported mild, transient side effects.
    • PFEs show potential in specialized applications like tumor oxygenation and infant respiratory support.

    Conclusions:

    • Safe and effective artificial oxygen carriers have the potential to significantly impact medical practice.
    • PFEs are unlikely to replace red blood cells for anemia treatment due to short intravascular survival.
    • Further research and clinical validation are crucial for FDA approval and widespread adoption of PFE technology.