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Related Experiment Videos

Exploiting temperature dependence to improve selectivity in membrane-based plasmapheresis.

S K Gautam1, S Jindal, C Kudva

  • 1School of Biomedical Engineering, Indian Institute of Technology, Bombay, India.

Transfusion Science
|May 8, 1995
PubMed
Summary
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Increasing temperature in membrane plasmapheresis enhances membrane flux, sieving, and fouling by increasing effective pore size. This temperature effect can be leveraged to modify the separation spectrum in plasmapheresis procedures.

Area of Science:

  • Biomedical Engineering
  • Materials Science

Background:

  • Membrane plasmapheresis is a medical procedure to remove harmful substances from blood.
  • Understanding temperature effects is crucial for optimizing membrane performance.

Purpose of the Study:

  • To investigate the impact of temperature on cross-flow membrane plasmapheresis.
  • To characterize filtration and sieving properties of polyvinylidene fluoride (PVDF) membranes at varying temperatures.

Main Methods:

  • Utilized hydrophilic PVDF Durapore membranes (0.65 micron pore size, 30 cm2 area) in a thin-channel device.
  • Employed goat's blood as the working fluid and performed experiments at 10, 20, 30, and 40°C.
  • Assessed normal saline flux and sieving coefficients for albumin, immunoglobulins, and fibrinogen.

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Main Results:

  • Higher temperatures led to an increased "effective" pore size of the membranes.
  • Flux, sieving, and fouling all increased with rising temperatures.
  • Steady-state parameters and permeate/feed samples were analyzed.

Conclusions:

  • Temperature significantly influences membrane plasmapheresis performance.
  • Exploiting temperature effects offers a potential strategy to modulate the sieving spectrum.
  • This finding could lead to improved control over plasmapheresis selectivity.