Related Experiment Video
Updated: Aug 11, 2026
07:01
An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
Published on: April 17, 2013
[Thyroid cancer in childhood (author's transl)]
Anales Espanoles De Pediatria
|November 1, 1976
Summary
Thyroid cancer in children is rare but requires prompt diagnosis. Early detection and biopsy are crucial for effective treatment and favorable outcomes, avoiding risks of radiotherapy.
Area of Science:
- Pediatric Oncology
- Endocrinology
- Cancer Research
Background:
- Thyroid cancer is an uncommon malignancy in pediatric patients.
- Understanding the etiologic, clinical, and therapeutic aspects is vital for managing this rare disease.
Observation:
- Presents three pediatric cases of thyroid cancer.
- Highlights the diagnostic challenge of persistent laterocervical adenopathies.
- Emphasizes the need for high clinical suspicion in children with neck masses.
Findings:
- Local radiotherapy poses significant risks in pediatric thyroid cancer.
- Biopsy is essential for confirming the diagnosis of thyroid cancer.
- The reported cases demonstrated a favorable clinical course with appropriate management.
Implications:
- Clinicians should consider thyroid cancer in children presenting with persistent cervical lymphadenopathy.
- Diagnostic confirmation via biopsy is paramount.
- Careful consideration of therapeutic strategies, minimizing risks associated with radiotherapy, is necessary for favorable outcomes in pediatric thyroid cancer.
Related Concept Videos
02:18Cancer
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
01:03Rous Sarcoma Virus (RSV) and Cancer
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
01:23The Thyroid Gland
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
01:20Synthesis and Regulation of Thyroid Hormones
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The iodine is then...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The iodine is then...