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A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
Published on: May 14, 2013
Coronary artery stenting in active duty soldiers
D Ebersole1, L Miller, S R Bailey
1Department of Medicine, Brooke Army Medical Center, Fort Sam Houston, Texas 78234-6262, USA.
Insights
Palmaz-Schatz coronary stenting shows promising results for active duty soldiers with coronary artery disease, demonstrating high angiographic success and low restenosis rates. This intervention may offer a valuable long-term treatment option for this population.
Area of Science:
- Cardiology
- Interventional Cardiology
- Vascular Surgery
Background:
- Coronary artery disease (CAD) treatment in young patients requires consideration of long-term outcomes and potential repeat interventions.
- Palmaz-Schatz coronary stents can reduce restenosis but carry risks of bleeding and vascular complications.
Purpose of the Study:
- To evaluate the efficacy and safety of intracoronary stenting using Palmaz-Schatz stents in young active duty soldiers with CAD.
Main Methods:
- A cohort of fifteen active duty soldiers (age 37-53) underwent elective Palmaz-Schatz stent placement between March 1988 and December 1994.
- Assessed for angiographic success, complications, and 6-month angiographic follow-up.
- Monitored clinical outcomes up to a mean of 33 months post-procedure.
Main Results:
- Achieved 100% angiographic success with no procedural complications.
- Six-month angiographic follow-up in 13 patients showed 8% restenosis and no target vessel revascularization.
- Long-term follow-up revealed one death (7%) from unrelated CAD progression and one revascularization (7%) for silent ischemia at 24 months.
Conclusions:
- Intracoronary stenting with Palmaz-Schatz stents appears safe and effective in active duty soldiers with CAD.
- Preliminary results suggest a significant role for this intervention in managing CAD in this specific demographic.
Abstract:
The treatment of coronary artery disease in young patients must take into account the long-term success of the treatment modality and the possibility of repeat interventions. Elective placement of Palmaz-Schatz coronary stents have been shown to reduce six month restenosis rates in discrete, de novo lesions in native coronary arteries albeit at a significant risk of bleeding and vascular complications. The present study was undertaken to evaluate the role of intracoronary stenting in young active duty soldiers. Between March 1988 and December 1994, fifteen active duty soldiers (age 37 to 53 years) underwent elective placement of one or more Palmaz-Schatz coronary stents at our institution. Angiographic success was 100% with no complications (acute/subacute closure, bleeding requiring transfusion, vascular repair, myocardial infarction, death, or in-hospital coronary artery bypass grafting). Six month angiographic follow-up is available in 13 patients (87%) with angiographic restenosis in one patient (8%) and no target vessel revascularization at six months. Clinical follow-up is available on all patients at a mean of 33 months (range 6-65) after the procedure. There was one death (7%) attributed to progression of coronary disease in another vessel and one patient (7%) who underwent target vessel revascularization for silent ischemia at 24 months after the procedure. These preliminary encouraging results suggest there may be a significant role for intracoronary stenting in active duty soldiers with coronary artery disease.
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