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Updated: Aug 14, 2026
12:31
In Vivo Modeling of the Morbid Human Genome using Danio rerio
Published on: August 24, 2013
Abstract:
A simple method of estimating the frequency of heterozygotes among the dominants by test-making has been described; and then a maximum likelihood estimate is obtained by an iterative counting procedure. Eearly results of Haldane have been review and modified. Methods of estimating the gene frequencies, their ratio, and the inbreeding coefficient from test-mating results have also been given.
Related Concept Videos
01:20Monohybrid Crosses
Overview
01:49Law of Segregation
When crossing pea plants, Mendel noticed that one of the parental traits would sometimes disappear in the first generation of offspring, called the F1 generation, and could reappear in the next generation (F2). He concluded that one of the traits must be dominant over the other, thereby causing masking of one trait in the F1 generation. When he crossed the F1 plants, he found that 75% of the offspring in the F2 generation had the dominant phenotype, while 25% had the recessive phenotype.
01:39Test Cross
Alleles are different forms of the same gene. Humans and other diploid organisms inherit two alleles of every gene, one from each parent.
01:20Monohybrid Crosses
Overview
01:43Incomplete Dominance
Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
01:39Test Cross
Alleles are different forms of the same gene. Humans and other diploid organisms inherit two alleles of every gene, one from each parent.